Assistant Professor of Pharmaceutical and Health Economics | Pharmaceutical and Health Economics
Los Angeles, CA, UNITED STATES
William Padula is an expert in health economics, cost-effectiveness analysis, health services research, and quality improvement.
One reason why prescription drugs are often priced lower overseas is that many countries perform detailed assessments of the economic value of drugs and their benefits. These assessments result in hard bargaining with drug companies before the medicines are allowed into national health plans...view more
William V Padula, Madhuram Nagarajan, Patricia M Davidson, Peter J Pronovost
We evaluated pressure injury rates as an indicator of performance in a retrospective observational cohort of 55 US academic hospitals from the Vizient clinical database between 2007 and 2012. Pressure injuries were defined by US Agency for Healthcare Research and Quality (AHRQ) Patient Safety Indicator 3 (PSI-03) for stage 3, 4, and unstageable pressure injuries not present on admission in hospitalized adults. We compared ratios of board-certified wound care nurses per 1000 hospital beds to hospital-acquired pressure injury rates in these hospitals using mixed-effects regression of hospital quarters.
Junichi Ishigami, William V Padula, Morgan E Grams, Alexander R Chang, Bernard Jaar, Ron T Gansevoort, John FP Bridges, Csaba P Kovesdy, Shinichi Uchida, Josef Coresh, Kunihiro Matsushita
Pneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized.
William V Padula, Benjo A Delarmente
Our objective was to estimate the US national cost burden of hospital‐acquired pressure injury (HAPI) using economic simulation methods. We created a Markov simulation to estimate costs for staged pressure injuries acquired during hospitalisation from the hospital perspective. The model analysed outcomes of hospitalised adults with acute illness in 1‐day cycles until all patients were terminated at the point of discharge or death. Simulations that developed a staged pressure injury after 4 days could advance from Stages 1 to 4 and accrue additional costs for Stages 3 and 4. We measured costs in 2016 US dollars representing the total cost of acute care attributable to HAPI incidence at the patient level and for the entire United States based on the previously reported epidemiology of pressure injury. US HAPI costs could exceed $26.8 billion. About 59% of these costs are disproportionately attributable to a small rate of Stages 3 and 4 full‐thickness wounds, which occupy clinician time and hospital resources. HAPIs remain a concern with regard to hospital quality in addition to being a major source of economic burden on the US health care system. Hospitals should invest more in quality improvement of early detection and care for pressure injury to avoid higher costs.
Anne Sohrt, Anders Mærkedahl, William V Padula
The objective was to investigate the cost effectiveness of using single-use EEG-CE instead of reusable EEG-CE when the risk of sepsis is considered.
M Kelley, WV Padula
Hospital-acquired pressure injuries (HAPIs) result in over 60,000 deaths in the U.S. at a societal cost of $26 billion. Early detection of those at greatest risk could improve outcomes. The Braden Scale is a HAPI risk-assessment tool, with scores collected in patient charts. Our first objective was to develop a machine learning algorithm to predict future Braden score trajectories from electronic health records (EHR). Second, we applied constrained optimization to the database to improve predictive efficiency.