Gul Afshan, Ph.D. profile photo

Gul Afshan, Ph.D.

Professor | Physics and Chemistry

Milwaukee, WI, UNITED STATES

Dr. Gul Afshan's areas of expertise are in microbiology and biomolecular engineering.

Education, Licensure and Certification

Ph.D.

Biochemistry, University of Wisconsin-Milwaukee

1999

M.Phil

Chemistry, Quaid-i-Azam University

1987

M.S.

Chemistry, Quaid-i-Azam University

1985

B.S.

Biology, Lahore College for Women

1981

Biography

Dr. Gul Afshan is a biochemist/molecular biologist with a passion for studying microscopic objects and genome science. She founded the undergraduate biomolecular engineering degree program at Milwaukee School of Engineerig and firmly believes all students should have an insight on what genome science is. Afshan teaches courses in biotechnology, chemistry, microbiology, nutrition, genomics, synthetic biology, biomolecular engineering, metabolic engineering and biochemistry in the Physics and Chemistry Department.

Areas of Expertise

MicrobiologyBiomolecular EngineeringBiochemistry

Accomplishments

Finalist for the Distinctive Werwath Teacher's Award, MSOE

2011

ASEE North Midwest Outstanding Educator Award

2009

Outstanding Mentor Award, MSOE

2006

Falk Engineering Educator Award, MSOE

2005

Finalist for the Falk Excellent Engineering Educator Award, MSOE

2004

Affiliations

  • American Institute of Chemical Engineers (AIChE) : Member
  • Society for Biological Engineering, SBE and AIChE Technological Community : Member
  • American Society for Engineering Education (ASEE) : Member
  • MSOE School of Nursing Honor Society : Member
  • Biotechnology Industry Organization (BIO) : Member
  • Biomedical Research Alliance of New York Institutional Biosafety Committee (BRANY IBC) : Member

Social

Media Appearances

MSOE to Offer BioMolecular Engineering Degree

Wisconsin Advanced Technology Advocates, Inc.  

2008-10-01

“The coming time is the BIOTIME … actually we are already living in it,” said Dr. Gul Afshan, associate professor in the Physics and Chemistry Department and BioMolecular Engineering program architect at MSOE. “BioMolecular Engineers are going to be truly the universal engineers of the future, capable of working all over the world in a wide range of roles and industries.”

view more

Event and Speaking Appearances

Seminar at Kiwanis's Club on BioMolecular Engineering Advances in the society

2012  

Leadership Seminar at Whitefish Bay High School on Cultural Diversity

2012  

Leadership Seminar to talk to high school groups about immigration and society

2011  Carroll University, Waukesha, WI

Seminar Series on Biology and Engineering

2011  Whitefish Bay High School

Experiences in the Fields of Engineering

2011  Women Faculty at MSOE

Research Grants

An Interdisciplinary Approach to Biological Energy Transfer Cross Institutional Collaboration and Adaptation

National Science Foundation $200,000

This project creates new physical models and digital instructional materials to help students understand photosynthesis, the process by which living organisms trap energy from the sun in food. During photosynthesis, green plants, algae and some microbes fix carbon dioxide from the air into organic molecules, the food upon which all living things depend. By removing carbon dioxide from the atmosphere, it also helps to control the build-up of this greenhouse gas. In addition some molecules made this way become biofuel, a renewable source of energy. Therefore this is an important process to understand. The models are used in a variety of undergraduate courses along with those previously created and tested by the SUN (Students Understanding eNergy) Project. Together these instructional materials allow undergraduates to enact both photosynthesis and cellular respiration, the process by which all living things move stored energy from food to ATP, the chemical currency required to power life. These topics are difficult for undergraduates to understand. They involve electrons moving along a particular path in protein complexes found in two cellular compartments, the chloroplast and the mitochondrion. A team from University of Wisconsin at Madison, University of Wisconsin at Milwaukee, The Scripps Research Institute, and Milwaukee School of Engineering (the lead institution) develops scale models that accurately represent the structures of the proteins involved in photosynthesis. It also creates web-based instructional materials that integrate knowledge of the biological structures with their functions. The models and digital learning tools are tested in cell biology, biochemistry, and physics classes at the cooperating institutions, and then refined for broader distribution. Ultimately they improve student learning. They also impact student persistence as science majors nationwide, since many students find these abstract concepts to be so difficult that they change their major. This project is being jointly funded by the Directorate for Biological Sciences, Division of Biological Infrastructure and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts toward Vision and Change in Undergraduate Biology Education.

A BioMolecular Engineering Program at MSOE

MSOE $6,000,000

A proposal total amount endowed to MSOE was $6,000,000.

Selected Publications

Promoting Multidisciplinary Education and Gender Diversity by Integrating Sciences into a New Biomolecular Engineering Curriculum | ASEE North Midwest Sectional Conferenc

Afshan, G., Mallman, J., Schenstrom, A.

2009

Depletion of cellular iron by BPS and ascorbate: Effect on toxicity of adriamycin | Free Radical Biology and Medicine

Nyayapati, S., Afshan, G., Lornitzo, F., Byrnes, R.W., Petering, D.H.

1996

A new method was developed that reduces the intracellular iron content of cells grown in serumcontaining culture without involving the significant uptake of iron-chelating agents into cells. Negatively charged bathophenanthrolinedisulfonate (BPS), together with ascorbate, caused cells to lose much of their cellular iron without causing much depression in HL-60 or H9c2 (2-1) cell proliferation over a 48-h period. When added to serum supplemented RPMI-1640 culture media, BPS and ascorbate efficiently reduced and competed for iron in Fe(III) transferrin to form Fe(II)(BPS)3. The reaction also occurred with purified human iron-transferrin. When cells were incubated with growth medium containing serum that had been treated with BPS and ascorbate for 24 h, little or no BPS2− or Fe(II)(BPS)34− entered the cells, according to direct measurements and in agreement with the highly unfavorable 1-octanol/water partition coefficients for these molecules. However, iron was mobilized out of both cell types. After 24 h incubation of cells in this medium, there was no change in the activities of catalase and superoxide dismutase, or in the concentration of glutathione. Glutathione peroxidase was elevated 9%. Using HL-60 and H9c2 (2-1) cells made iron deficient with BPS and ascorbate, HL-60 cells grown in defined-growth media in the absence of iron-pyridoxal isonicotinoyl hydrazone, or Euglena gracilis cells maintained in a defined medium that was rigorously depleted of iron, it was shown that the cytotoxicity of adriamycin is markedly dependent on the presence of iron in each type of cell. Similar results were obtained when HL-60 cells were grown in RPMI-1640 culture medium and serum that had been incubated for 24 h in BPS and ascorbate and then chromatographed over a Bio-Rad desalting column to remove small molecules including BPS, ascorbate, and Fe(II)(BPS)3.

view more