Floyd D. Gottwald Jr. Chair and chair, Department of Chemical and Life Science Engineering
Engineering West Hall, Room 403A, Richmond, VA, UNITED STATES
Professor Gupton's research is focused on the development of new technologies that will streamline organic synthesis
Pharma Integrates online
Last summer, Virginia Commonwealth University (VCU) in Richmond, VA (USA), was awarded a $25 million grant from the Bill & Melinda Gates Foundation to establish the Medicines for All Institute (M4ALL) and to fund the institute’s work on a wide range of essential global health treatments. With this grant, the institute helps to lower cost and increase access to lifesaving medications for HIV/AIDS, malaria, tuberculosis and other diseases around the world. B. Frank Gupton, PhD, professor at VCU and leader of the Medicines for All Institute, has previously developed innovative models that reduce the cost of manufacturing HIV/AIDS treatments by accelerating the way the active ingredients in these medications are synthesised. The current award by the foundation will fund the institute’s work on 13 global health drugs during the next 5 years.view more
Dr. B. Frank Gupton, Virgina Commonwealth University Department of Chemical and Life Science Engineering, shares details on his latest innovative research. He is focused on the development and application of new technologies that will streamline organic synthesis through process intensification. The overall interest is in applying these principals towards the development of new catalyst systems that can be used in concert with continuous chemical processing (flow reactor technology) to streamline the synthesis of pharmaceutical active ingredients (API’s).view more
Commonwealth Times print
The internationally recognized Bill and Melinda Gates Foundation awarded VCU’s School of Engineering $25 million dollars to develop a revamped medical institute this week. The Medicines for All Institute will be a new medical facility that will be charged with the task of creating life-saving medicine that is affordable and readily accessible for people all around the world. Some of the medicines that are in the works include vaccines and treatment for HIV/AIDS, malaria and tuberculosis. This is the second grant, following a $15 million donation from the Gates Foundation distributed over the past three years, to the institute. It is lead by B. Frank Gupton, who serves as the Chair of the Department of Chemical and Life Science Engineering. In a press conference held on Aug. 24, Gupton applauded the Gate’s Foundation for investing in the future of the institute. “The funds and the milestones on the grant are not only linked to the drugs that we are optimizing, but in how we create a sustainable organization,” Gupton said. The institute’s goal is to speed up the process of developing certain medications that are used globally without increasing the cost.view more
Philanthropy News Digest online
Virginia Commonwealth University in Richmond has announced a $25 million grant from the Bill & Melinda Gates Foundation in support of efforts to expand global access to live-saving drugs. The largest grant ever from a private entity to VCU will establish the Medicines for All Institute in the School of Engineering and fund work on a wide range of essential treatments for HIV/AIDS, malaria, tuberculosis, and other diseases. The Gates Foundation has awarded grants totaling nearly $15 million to the Medicines for All program over the last four years, during which researchers developed a model for accelerating the creation of more efficient ways of synthesizing the active ingredients in AIDS drugs, thus lowering their costs. Medicines for All also has worked with the Clinton Health Access Initiative and other partners to transfer the new processes to manufacturers so that more drugs and treatments reach communities in need. B. Frank Gupton, the Floyd D. Gottwald Professor and Chair of the Department of Chemical and Life Science Engineering at VCU, said that while grants from the Gates Foundation to date have supported work on a single drug at a time, the latest award will enable researchers to study multiple drugs in parallel. The grant also will fund the institute’s work on an additional thirteen global health treatments over the next five years. "These funds will allow us to bring in additional senior scientists and allow them to equip their labs and staff them immediately," said Gupton. "The funds and the milestones on the grant are not only linked to the drugs that we are optimizing but in how we create a sustainable organization."view more
Virginia Public Radio radio
Virginia Commonwealth University in Richmond has received the largest private grant in history: 25 million dollars from the Bill and Melinda Gates Foundation. The money will support the school’s “Medicines for All” research. Virginia’s Governor was on hand at the announcement. Mallory Noe-Payne reports.view more
The Virginia Commonwealth University School of Engineering has been awarded a $25 million grant from the Bill & Melinda Gates Foundation to establish the Medicines for All Institute and to fund the institute’s work on a wide range of essential global health treatments. With this grant, the institute can help increase access to lifesaving medications for HIV/AIDS, malaria, tuberculosis and other diseases around the world. B. Frank Gupton, Ph.D., the Floyd D. Gottwald Professor and Chair of the Department of Chemical and Life Science Engineering in the VCU School of Engineering, will continue to lead and serve as principal investigator for Medicines for All. Over the past four years, the Gates Foundation has awarded nearly $15 million to Medicines for All. During this time and with this support, Medicines for All has developed an innovative model that reduces the cost of manufacturing AIDS treatments such as nevirapine by accelerating the creation of more efficient ways of synthesizing the active ingredients in the medications. The institute has also worked closely with the Clinton Health Access Initiative and other implementation partners to transfer the new processes to manufacturers so that more medications can reach communities in need. The success of Gupton’s team was evident from the initial grant. For instance, it was able to reduce the cost of nevirapine by more than 10 percent in less than one year. “The Gates Foundation gave us $4.4 million to work on this first target molecule,” Gupton said. “If we reduced the cost 10 percent, then the payback period on the $4.4 million would be about a year. With now sustained savings of more than 10 percent, the payback period has been even shorter.”view more
Virginia Commonwealth University in Richmond has received the largest private grant in history: 25 million dollars from the Bill and Melinda Gates Foundation. The money will support the school’s “Medicines for All” research. Virginia’s Governor was on hand at the announcement. The Gates Foundation has already given $15 million dollars to the effort, meaning VCU has now received $40 million overall. Virginia’s Governor helped seal the deal back in January. “I’m really proud of this, actually Dr. Gupton and I -- I was part of the pitch, one of the pitches we had, we went out to San Francisco and you would have thought I invented medicine the way I was sitting there, he gave me some great talking points," laughed the Governor during a press conference announcing the grant. The “he” is Frank Gupton. For years, Gupton and a small team have been working on making life-saving drugs at the cheapest cost possible. They targets the active ingredients, refining manufacturing processes. Last year, they developed a new way to make the active ingredient in an HIV drug, lowering costs by 40-percent. The Gates Foundation was so pleased they wanted Gupton to work on more than one drug at a time. “And I said ‘No I can’t do that, there’s only one of me.’ And then they said well what if we were able to give you the funding to be able to recruit additional people to come in and work in parallel with you on other drugs,” says Guptonview more
Richmond Times Dispatch print
The Bill & Melinda Gates Foundation has awarded the Virginia Commonwealth University School of Engineering $25 million to create the Medicines for All Institute, a program that will seek ways to make life-saving medications less costly and more available worldwide. The grant - which is the largest the university has ever received from a private entity - was announced Thursday at an event held at the Biotechnology Research Park's Biotech Eight building on North Fifth Street, where the institute has set up a 30,000-square-foot space. Frank Gupton - chair of the Department of Chemical and Life Science Engineering at the School of Engineering - will lead the institute as it seeks ways to make medications to treat HIV/AIDS, malaria, tuberculosis and other diseases more accessible by reducing the manufacturing cost. "These are medicines for the most part that are either in the forms of generics or would-be generics," said Barbara D. Boyan, dean of the School of Engineering. "The costs of these medicines has not risen to a great extent, but to many people in the world they're still too expensive and just too difficult to have access to." Gupton and his team have received several smaller grants from the Gates Foundation over the past three years, using those funds to make manufacturing less costly over an 18-month period for one drug at a time. "We had to prove ourselves," Gupton said. "We went through a pretty rigorous proof of concept period for about three years where they gave us one drug after another to work on. If we didn't succeed, that check wouldn't have been written."view more
Virginia Business online
The Virginia Commonwealth School of Engineering announced Thursday it has received a $25 million grant from the Bill & Melinda Gates Foundation to build on its efforts to reduce the costs of lifesaving medications. The grant will build on VCU’s Medicines for All Initiative, which has found ways to drive down the cost of three drugs used to treat HIV patients. The new grant will turn the program into the Medicines for All Institute, allowing it to grow and test multiple medicines at one time. The grant was announced Thursday at event held at the Virginia Biotechnology Research Park, which was attended by Gov. Terry McAuliffe and VCU President Michael Rao. The Medicines for All initiative previously received a total of $15 million from the Gates Foundation to test three drugs. The goal of its first grant of $4.7 million was to reduce the cost of Nevirapine, a drug used to treat and prevent HIV and AIDs, by 10 percent. Researchers, however, were able to reduce the cost of producing the drug by 40 percent. “The concept started with a simple idea to increase access to global health care,” Frank Gupton, chair of the VCU Department of Life Science and Engineering and principal investigator for Medicines for All, said of the program. “We have to use 21st century capabilities to make these drugs and make them affordable to everyone.”view more
Richmond BizSense online
On the first day of classes for the fall semester, administrators announced the VCU School of Engineering has been awarded a $25 million grant from the Bill & Melinda Gates Foundation – the largest grant in the engineering school’s history and the university’s second-largest. The grant will be used to further establish the school’s Medicines for All Institute, formed in 2014 to reduce costs of manufacturing pharmaceutical products and increase global access to medications. The institute is led by Frank Gupton, professor and chairman of the school’s department of chemical and life science engineering. Gupton was among several speakers at Thursday’s announcement, including Gov. Terry McAuliffe, VCU President Michael Rao and Barbara Boyan, dean of the school. “I think everyone understands the challenge that we’re faced with as far as addressing this issue of access to affordable healthcare,” Gupton said. “We’re not just here to solve healthcare problems,” he said. “We’re here to train the scientists of the 21st century.”view more
VASEM Report print
Ling noted that one of the applications he is particularly excited about is providing anti-retroviral therapies for Africans with HIV, a project he is exploring with colleagues at Virginia Commonwealth University. “The drugs could be delivered by drone to patients,” he said. The VCU team, led by Frank Gupton, chair of Chemical and Life Science Engineering, has been funded by the NSF, DARPA and the Bill & Melinda Gates foundation to develop flow chemistry methods that can reduce the cost of the ingredients for drugs needed to treat critical diseases like HIV, tuberculosis, and cancer.view more
Richmond Times-Dispatch print
The School of Engineering received about $5 million from the Bill & Melinda Gates Foundation to create a more cost-effective way to manufacture Dolutegravir. It is the third such grant the foundation has awarded the school. The lead investigator, B. Frank Gupton, professor and chair in the VCU Department of Chemical and Life Science Engineering, said the drug is likely to become a first-line therapy for HIV/AIDS.view more
WVTF / RadioIQ (NPR Affiliate) radio
Frank Gupton used to work for a major pharmaceutical company, so he knows the ins and outs of making drugs. That means he also knows how, often, many drugs that were invented decades ago, could be created for far cheaper today. Gupton says you’d think manufacturer’s would take a look at that, but they don’t.view more
Life Science Leader online
In his “second career,” professor Gupton has given TED talks and received grants totaling nearly $10 million from the Bill & Melinda Gates Foundation. The title of his talk was “Streamlining Pharmaceutical Processes: The ‘Medicines For All Initiative,’ a multidisciplinary project he is leading that seeks cheaper and more efficient ways to manufacture drugs.Gupton noted how the cost structure between a generic and patented drug is quite dramatic.view more
B. Frank Gupton, chair of the Virginia Commonwealth University School of Engineering’s Department of Chemical and Life Science Engineering, is one of the state’s key innovators. He served on McAuliffe’s biosciences technology roundtable last year and recently helped form the Virginia Drug Development Consortium, a collaboration involving VCU, the University of Virginia and Virginia Tech. “We’re trying to take the innovations that are occurring at the different universities in drug discovery [and] move them down the pipeline and increase the intellectual property value of them,” he explains...view more
"We completed the first phase and we've gotten the chemistry to where it's probably the lowest-cost process you could imagine, using really cheap, inexpensive raw materials and streamlining the chemistry for the process," lead researcher B. Frank Gupton said in the study. "We've reported our results to the Gates Foundation and I believe that they were very pleased with our progress." ...view more
University of Richmond, Richmond, VA.
SelectBio Flow Chemistry Congress San Diego, CA.
Virginia Polytechnic Institute and State University Blacksburg, VA.
University of Mainz Mainz, Germany
CPAC Annual Meeting Rome, Italy
National Science Foundation $ 11,500
April 2014 – Feb. 2015
Boehringer Ingelheim Pharmaceuticals, Inc. $ 50,000
June 2013 - Aug. 2014
Clinton Health Access Initiative $ 24,000
May 2013 – Oct. 2014
Clinton Health Access Initiative $ Clinton Health Access Initiative
May 2012 – March 2013
VCU Presidential Research Incentive Program Award $ 40,000
Jan. 2010 - Dec. 2010
Herein, we report a facile and efficient one-step method for the synthesis of highly active, Pd/Fe 3 O 4 nanoparticles supported on graphene nanosheets (Pd/Fe 3 O 4/G) that exhibit excellent catalytic activity for Suzuki and Heck coupling reactions and that can be ...
N-Chelation-directed C–H activation reactions that utilize the Pd (II)/Pd (IV) catalytic cycle have been previously reported. To date, these reactions employ only homogeneous palladium catalysts. The first use of a solid-supported Pd (II) catalyst [Pd (II) nanoparticles ...
An efficient, sustainable, and continuous method for the preparation of graphene supported palladium nanoparticles (Pd/G) has been developed using microwave irradiation as a heating source for the metal deposition process. The Pd/G produced from this method ...
In this paper, we report a simple, versatile, and rapid method for the synthesis of Pd nanoparticle catalysts supported on Fe 3 O 4, Co 3 O 4, and Ni (OH) 2 nanoplates via microwave irradiation. The important advantage of microwave dielectric heating over ...
Palladium nanoparticles supported on single-or multi-walled carbon nanotubes (Pd/SWCNT and Pd/MWCNT) were prepared by a rapid, solventless method that does not require reducing agents or electric current. The method involves a straightforward process using ...