Senior Lecturer in Dementia and Complexity in Later Life
Norwich, UNITED KINGDOM
His research is in the role of sleep in brain health and in dementia.
M.Sc., Molecular Medicine and Neuroscience
Daily Mail online
The prediction, according to Dr Alpar Lazar from the University’s School of Health Sciences, is that those at the highest genetic risk of dementia will do significantly worse in the tests than others when sleep-deprived.view more
Health Europa online
“A symptom of Alzheimer’s is poor sleep. Good sleep is central to maintaining cognitive performance – such as attention and memory as well as general brain health. “Sleep deficits have been shown to be early markers in certain brain disorders. “But is it Alzheimer’s causing sleep problems, or do sleep problems modulate or contribute to the disease process?view more
Eastern Daily Press online
Lead researcher Dr Alpar Lazar, from UEA’s School of Health Sciences, said: “We live in an ageing society, and sleep disturbances and dementia are two significant health problems in older adults.view more
BBC News online
Lead researcher Dr Alpar Lazar, from UEA's School of Health Sciences, said: "We live in an ageing society, and sleep disturbances and dementia are two significant health problems in older adults.view more
Daily Mail online
Sleep resets connections in the brain that are important for memory — eliminating weak connections between the brain cells and maintaining the strongest ones, adds Dr Alpar Lazar, a lecturer in dementia at the University of East Anglia.view more
Sleep and circadian rhythms are considered to be important determinants of mental and physical health. Epidemiological studies have established the contribution of self‐reported sleep duration, sleep quality and chronotype to health outcomes. Mental health and sleep problems are more common in women and men are more likely to be evening types.
Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD.
It has previously been reported that EEG sigma (10–15 Hz) activity during sleep exhibits infraslow oscillations (ISO) with a period of 50 s. However, a detailed analysis of the ISO of individually identified sleep spindles is not available.
Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington’s disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse.
Obsessive–compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors that severely encumber daily functioning. OCD patients seem to exhibit sleep disturbances, especially delayed bedtimes that reflect disrupted circadian rhythmicity.