Senior Lecturer, Cognitive Science | Cognitive Science
Troy, NY, UNITED STATES, Carnegie, 304
Neuroscientist with extensive research into body, brain, and mind relationships related to brain health, social cognition and emotions.
Ph.D., Behavioral Neuroscience
B.A., East Asian Studies
Boston Globe print
... Even the anticipation of traveling can trigger happiness, said Alicia Walf, a neuroscientist at Rensselaer Polytechnic Institute. Walf doesn’t need surveys or research studies to see how much people are doing that. She hears it in conversations with her friends and sees it on their social media. And she gets it. When people travel, especially for pleasure, Walf said, it reduces their stress. A laid-back beach trip means “staying at a hotel, going to restaurants, no need to clean. When we travel, especially for pleasure, we are momentarily away from our daily hassles and stressors right in front of us, like a huge pile of laundry to be folded.” ...view more
Fast Company print
... Here are five things you can do to help you buckle down and start getting things done: PURGE DISTRACTIONS Take a few moments to reduce distractions in your environment to minimize their impact, says neuroscientist Alicia Walf, a senior lecturer at Rensselaer Polytechnic Institute. Are there things in your environment that are draining your attention? Address them. “Whether it’s your phone, or even maybe if you have a window open and you’re looking outside, and that’s focusing on your work, to try to reduce those things also in your environment,” she says. ...view more
Brains Byte Back online
Our brain is undeniably an incredibly complex and impressive object, and this is best demonstrated with brain plasticity, a term that refers to the brain’s ability to change and adapt as a result of experience. To better understand how the brain does this and the processes that take place when we learn new skills, we spoke with Alicia Walf, Ph.D., a neuroscientist and a senior lecturer in the Department of Cognitive Science at Rensselaer. Walf studies the brain mechanisms of stress and reproductive hormones as they relate to behavior and cognition, brain plasticity, and brain health over the lifespan.view more
Reader's Digest print
Most people, at some point or another, have experienced the feeling of infatuation—or at least found themselves in a situation where they couldn’t stop staring at someone they found physically attractive. Sure, you could write that off as having a “type,” but that still doesn’t explain why that person, in particular, caught your eye. (More on that in a minute.) But what about when you’re drawn to someone who isn’t, let’s say, “conventionally attractive”? There’s really where science enters the picture—although it’s still not entirely clear how it all works. “The mechanisms of human attraction are not fully understood, but involve basic hormonally-modified brain circuitry across many mammal species,” Alicia A. Walf, PhD, senior lecturer in the cognitive science department at Rensselaer Polytechnic Institute, tells Reader’s Digest. “[Understanding] these mechanisms of human attraction can also reveal basic mechanisms of other motivated and rewarding behaviors, which are likely to be shared.”view more
As if the pandemic wasn't enough to trigger stress, add to that the election. So how do we handle all this tension? Normally, a little stress is good. It motivates us to take on new challenges. However, when it's chronic like the times we're living in, we have to be aware of how it's affecting us and take action to limit the problems it can cause. Dr. Alicia Walf is neuroscientist and senior lecturer at RPI. As she points out, chronic stress affects our emotional and physical well-being.view more
Alicia Walf, Ph.D., a neuroscientist and senior lecturer in the Department of Cognitive Science at Rensselaer Polytechnic Institute in Troy, New York, emphasized that desensitization amid ongoing trauma is “natural and adaptive,” and suggested that it helps us to emotionally regulate ourselves in chronically traumatic situations. “We are not able to mount the same intense stress and emotional response as we did in the beginning of the pandemic,” Walf said.view more
If you're ticklish, you know that strange mix of pleasure, surprise, and weirdness when someone finds your ticklish spots. But have you noticed that some people aren't ticklish? And some people enjoy being tickled and others who find it miserable? Good news: It's all normal. "As with any sensory experience, people have different levels of sensitivity to touch and tickle," says Alicia Walf, PhD, a senior lecturer in cognitive science at Rensselaer Polytechnic Institute in Troy, New York.view more
Aging happens, and with it often comes some changes to learning, memory and overall cognitive health. But just like with your physical health, you can give the mind a workout to help mitigate the effects of aging on your brain. "Although aging is a part of life, significant losses in cognitive abilities, such as what occurs with dementia, do not have to be," says Alicia Walf, PhD, a neuroscientist and a senior lecturer in the Department of Cognitive Science at Rensselaer Polytechnic Institute.view more
Elemental Medium online
Anger and fear both generate a basic stress response, collectively called fight or flight. Anger makes us want to fight, and fear makes us want to flee. The system is evolutionarily set up to keep us alive, to face the threat of an invading tribe or to run from a tiger. But it can be activated by all kinds of things, says neuroscientist Alicia Walf, PhD, a senior lecturer in cognitive science at Rensselaer Polytechnic Institute.view more
Architect Magazine print
Alicia Walf, a neuroscientist at Rensselaer Polytechnic Institute, in Troy, N.Y., says that the accessibility of biometric data today means that architecture can become personalized in much the same way as doctors are experimenting with personalized medicines.view more
Reid LD, Avens FE, Walf AA.
This review provides the rationale for implementing cognitive behavioral therapy (CBT) for the prevention of Alzheimer’s disease (AD). There are known risk factors associated with the development of AD, some of which may be ameliorated with CBT. We posit that treating the risk factors of inactivity, poor diet, hyposmia and anosmia, sleep disorders and lack of regularly engaged challenging cognitive activity will modify the physiology of the brain sufficiently to avoid the accumulation of excess proteins, including amyloid beta, causal events in the development of AD. Further, the successful treatment of the listed risk factors is well within our technology to do so and, even further, it is cost effective. Also, there is considerable scientific literature to support the proposition that, if implemented by well-established practices, CBT will be effective and will be engaged by those of retirement age. That is, we present a biologically informed CBT for the prevention of the development of AD, i.e., an aspect of applied behavioral neuroscience.view more
Matalucci, B., Phillips, K., Walf, A.A., Dyson, A., & Draper, J.
How can building technologies accommodate different and often conflicting user preferences without dissolving the social cohesiveness, intrinsic of every architectural intervention? Individual thermal comfort has often been considered a negligible sensorial experience by modern heating and cooling technologies, and is often influenced by large-group norms. Alternatively, we propose that buildings are repositories of indoor microclimates that can be realized to provide personalized comfort, to create healthier environments, and to enhance the attributes of architectural interventions into haptic dimensions. In response, the goal of this study is to characterize an experimental framework that integrates responsive thermal systems with occupants’ direct and indirect experience, which includes stress response and biometric data. A computational model was used up to inform and analyze thermal perception of subjects, and later tested in a responsive physical installation. While results show that thermal comfort assessment is affected by individual differences including cognitive functions and biometrics, further computational efforts are needed to validate biometric indicators. Finally, the implications of personalized built environments are discussed with respect to future technology developments and possibilities of design driven by biometric data.view more
Walf AA, Koonce CJ, Frye CA.
This review explores the effects of female reproductive hormones, estrogens and progestogens, with a focus on progesterone and allopregnanolone, on object memory. Progesterone and its metabolites, in particular allopregnanolone, exert various effects on both cognitive and non-mnemonic functions in females. The well-known object recognition task is a valuable experimental paradigm that can be used to determine the effects and mechanisms of progestogens for mnemonic effects across the lifespan, which will be discussed herein. In this task there is little test-decay when different objects are used as targets and baseline valance for objects is controlled. This allows repeated testing, within-subjects designs, and longitudinal assessments, which aid understanding of changes in hormonal milieu. Objects are not aversive or food-based, which are hormone-sensitive factors. This review focuses on published data from our laboratory, and others, using the object recognition task in rodents to assess the role and mechanisms of progestogens throughout the lifespan. Improvements in object recognition performance of rodents are often associated with higher hormone levels in the hippocampus and prefrontal cortex during natural cycles, with hormone replacement following ovariectomy in young animals, or with aging. The capacity for reversal of age- and reproductive senescence-related decline in cognitive performance, and changes in neural plasticity that may be dissociated from peripheral effects with such decline, are discussed. The focus here will be on the effects of brain-derived factors, such as the neurosteroid, allopregnanolone, and other hormones, for enhancing object recognition across the lifespan.view more
Jensen EV, Jacobson HI, Walf AA, Frye CA.
In the 50 years since the initial reports of a cognate estrogen receptor (ER), much has been learned about the diverse effects and mechanisms of estrogens, such as 17β-estradiol (E2). This expert narrative review briefly summarizes perspectives and/or recent work of the authors, who have been addressing different aspects of estrogen action, but take a common approach of using alternative considerations to gain insight into mechanisms with clinical relevance, and inform future studies, regarding estrogen action. Their “Top Ten” favorite alternatives that are discussed herein are as follows. 1 — E2 has actions by binding to a receptor that do not require its enzymatic conversion. 2 — Using a different strategy for antibody binding could make the estrogen receptor (ER) more discernible. 3 — Blocking ERs, rather than E2 production, may be a useful strategy for breast cancer therapy. 4 — Secretion of α-fetoprotein (AFP), rather than only levels of E2 and/or progesterone, may influence breast cancer risk. 5 — A peptide derived from the active site of AFP can produce the same benefits of the entire endogenous protein in endocrine cancers. 6 — Differential distribution of ER subtypes in the body and brain may underlie specific effects of estrogens. 7 — ERβ may be sufficient for the trophic effects of estrogen in the brain, and ERα may be the primary target of trophic effects in the body. 8 — ERβ may play a role in the trophic effects of androgens, and may also be relevant in the periphery. 9 — Downstream of E2's effects at ERβ, there may be consequences for biosynthesis of progestogens and/or androgens. 10 — Changes in histones and/or other factors, which may be downstream of ERβ, potentially underlie the divergent effects of E2 in the brain and peripheral tissues.view more
The steroid, 17β‐oestradiol (E2) has pervasive psychological and physical effects throughout the lifespan. The question arises as to whether there are divergent oestrogen receptor (ER)‐mediated mechanisms for these effects in the central nervous system (CNS) and periphery. This review focuses on results of studies using a whole animal model (i.e. female rats and mice) to investigate the relative effects and mechanisms of oestrogens in the CNS and the periphery. By using this approach, it has been possible to differentiate the enhancing effects of E2 on behavioural processes mediated by the hippocampus, such as affective behaviour, and the trophic effects that increase tumourigenesis and uterine growth. Studies using pharmacological manipulations and knockout mice suggest that a likely mechanism underlying the beneficial effects of E2 for hippocampal function (but not proliferative effects in the body) involves actions at ERβ, changes in cell cycle/division (e.g. cyclin D1) and/or histone modifications. Thus, it may be possible to differentiate the beneficial effects of oestrogens through ERβ, particularly in the CNS, from the negative proliferative effects on peripheral, E2‐sensitive tissues.view more